Sodas, Other Sweet Drinks Tied to Higher Risk for Endometrial Cancer Study of 23,000 older women saw odds for a tumor rise as daily intake went up

FRIDAY, Nov. 22, 2013 (HealthDay News) -- Older women who drink lots of soda and other sugary beverages may be at higher risk for endometrial cancer, a new study suggests.
Endometrial cancer involves tumors in the lining of the uterus, and typically affects women in their 60s or 70s, according to the U.S. National Cancer Institute (NCI).
In the new NCI-funded study, researchers looked at data from more than 23,000 postmenopausal women in Iowa who were followed from 1986 to 2010.
They found that those who drank the largest amounts of sugar-sweetened beverages had a 78 percent higher risk for a tumor known as estrogen-dependent type I endometrial cancer.
The more sugar-sweetened beverages a woman drank, the greater her risk, according to the study published online Nov. 22 in the journal Cancer Epidemiology, Biomarkers & Prevention.
There was no link between endometrial cancers and consumption of sugar-free soft drinks, sweets/baked goods and starch.
In a journal news release, study author Maki Inoue-Choi said she wasn't surprised that increased intake of sugary drinks was tied to this estrogen-linked cancer.
"Other studies have shown increasing consumption of sugar-sweetened beverages has paralleled the increase in obesity," explained Inoue-Choi, who was a research associate at the University of Minnesota School of Public Health when the study was conducted. "Obese women tend to have higher levels of estrogens and insulin than women of normal weight, [and] increased levels of estrogens and insulin are established risk factors for endometrial cancer."
Inoue-Choi is currently a postdoctoral fellow at the NCI and the U.S. National Institute on Minority Health and Health Disparities.

Prediction of preeclampsia by uterine artery doppler at 20-24 weeks gestation

This study by Gallo DM, et al. –  aims to determine maternal characteristics affecting uterine artery pulsatility index (PI) in normal pregnancies at 20–24 weeks' gestation and examine in pregnancies with preeclampsia (PE) the relation between uterine artery PI multiple of the median (MoM) and severity of disease. In a normal pregnancy, uterine artery PI is affected by maternal characteristics, and in PE, uterine artery PI MoM is related to the severity of the disease.
Methods

• Uterine artery PI was measured at 20–24 weeks in 50,490 singleton pregnancies, including 1,442 (2.9%) that developed PE.
• Uterine artery PI was expressed as MoM after adjustment for maternal characteristics and corrected for adverse pregnancy outcomes.
• In PE, the correlation between uterine artery PI MoM with gestational age at delivery and birth weight Z–score was determined.

Results

• In the normal group there were significant independent contributions to uterine artery PI from gestational age, racial origin and prior history of PE, and/or small for gestational age (SGA).
• In the PE group, there was an inverse significant association between uterine artery PI MoM and both gestational age at delivery and birth weight Z–score (p < 0.0001).
• Uterine artery PI was above the 95th percentile (1.509 MoM) in 72.7, 36.1 and 14.9% of cases of PE requiring delivery at <34 34="" 37.4="" 55.6="" 80.2="" and="" for="" li="" pe="" percentages="" respectively="" sga="" the="" weeks="" were="" with="">