Saturday, February 27, 2016

CDC: Stillbirths Now Outnumber Infant Deaths in U.S.

(HealthDay News) — Stillbirths have eclipsed infant deaths for the first time in the United States, according to new research published in the U.S. Centers for Disease Control and Prevention's July 23 National Vital Statistics Report.
"The number of fetal deaths is now slightly higher than the number of infant deaths," report coauthor Elizabeth Gregory, M.P.H., a health statistician at the CDC's National Center for Health Statistics, told HealthDay. In 2013, there were 23,595 fetal deaths at 20 weeks of gestation or more, compared to 23,446 infant deaths. The report did not include abortions, Gregory said.
Although fetal death rates overall have remained largely unchanged, they are higher for certain populations, including teens, women aged 35 and over, and unmarried women, along with male fetuses and multiple fetuses, the researchers found. But significant racial disparities also emerged in the report.
In 2013, the fetal death rate for black women stood at 10.5 per 1,000 pregnancies, which was more than twice the rate for white women and Asian or Pacific Islander women, researchers found. The fetal death rate for American Indian or Alaska Native women was 27 percent higher than the rate for white women, while it was 7 percent higher for Hispanic women.

Zika Virus linked to Stillbirth

PLOS Neglected Tropical Diseases., 
Zika virus may be associated with hydrops fetalis and fetal demise, according to a case report published online.
Manoel Sarno, MD, PhD, from the Hospital Geral Roberto Santos in Salvador, Brazil, and colleagues present the case of a 20-year-old pregnant women with an ultrasound examination that showed intrauterine growth retardation of the fetus at the 18th gestational week. She was referred after a large Zika virus outbreak in Brazil.
The researchers note that severe microcephaly, hydranencephaly, intracranial calcifications, and destructive lesions of posterior fossa were identified in ultrasound examinations in the second and third trimesters; in addition, hydrothorax, ascites, and subcutaneous edema were observed. At the 32nd gestational week they performed an induced labor due to fetal demise and delivered a female fetus. Zika virus-specific real-time polymerase chain reaction amplification products were obtained from cerebral cortex, medulla oblongata, and cerebrospinal and amniotic fluid extracts; there were no detectable products from extracts of heart, lung, liver, vitreous body of the eye, or placenta.
"Given the recent spread of the virus, systematic investigation of spontaneous abortions and stillbirths may be warranted to evaluate the risk that Zika virus infection imparts on these outcomes," the authors write

Saturday, February 20, 2016

Lawyer mother booked under PC&PNDT


Gujarat files case under PNDT against mom

TNN | Mar 22, 2015, 04.35 AM IST
SURAT: In a first in Gujarat, a case of violation of the Pre-Conception and Pre-Natal Diagnostic Techniques (PCPNDT) Act was filed against a mother — Swati Dinesh Patil, resident of Nandurbar in Maharashtra — and her sister-in-law for sex determination of her foetus in Surat on Saturday. Until now, only doctors have been booked for PCPNDT violations in the state.

The FIR accusing a parent and family for PCPNDT violation is the fallout of the crackdown in an interstate sex determination racket being run by a homeopath doctor in Pandersara area.

Ramesh Kapadia, a quack, is a history-sheeter. "There are two PCPNDT violation cases pending against Kapadia in Gujarat high court. We have seized a mobile-sized sonography machine from him which he had hid in a helmet. The sonography was to be done in a flat. Such hush-hush operations indicate that the rot has set deep in society," said Dr Megha Mehta, chief district health officer (CDHO) Surat.

Dr Mehta said the operation has exposed a racket being run by an agent identified as Samadhan in Nandurbar who had tied up with Dr Kapadia and had sent women from Maharashtra for sex determination.

Probably for the first time, a patient from Pune has been booked under PCPNDT Act along with her mother, husband, and two gynecologists who allegedly aided the woman in an abortion of her own unborn female child. All of them were booked after an investigation which lasted for about 6 months. We have often seen radiologists and gynecologists being targeted indiscriminately by the government authorities under PCPNDT act. However, probably for the first time, the mother of two, who also is a lawyer by profession has been charged under PCPNDT act. The incident took place last year in Pune. An informant lodged a complaint with the police commissioner against the lawyer woman last year on August 19. The complaint was sent to local civic administration (Pune Municipal Corporation) for further legal action. After a long investigation, the authorities found that there was a substance in the complaint. The authorities investigated the documents which were seized and recorded the statements of various people as a part of an investigation. The qualified members from medical community were consulted which found that the foetus was normal and there was no evidence of bleeding or placental abnormality from USG which would warrant an abortion. The investigators also found that hospital sent the death information form to the municipal corporation on 23 June 2015, which mentioned the sex of the foetus as ‘female’. The medical records also showed that woman, who is a mother of two girls, frequently visited the alleged hospital for the treatment during the entire pregnancy. The abortion of the foetus was carried out on 23 June 2015 by one of the gynecologists. The woman was accompanied by her mother and the husband for the procedure. The case has been filed in the Judicial Magistrate First Class Court, Shivajinagar, Pune this year, alleging the violation of PCPNDT act 1994 and Rules 1996. The woman who is a practicing lawyer, is booked under 4(2), 6(B), 23 (3), Rule 18 (i), 18 (iii) and 18 (X) for not giving mandatory declaration under Rule 10 (1-A) and is liable for 3 years of imprisonment and/or ₹ 50,000 in fine. Mother and the husband of the woman have been booked for violating (2), 6(B), 23 (3), Rule 18 (i), 18 (iii) and 18 (X) for participating in sex determination and foeticide. The woman gynecologist (also the owner of hospital) is booked for violation of Section 4(3), 5,6,29 Rule 9(1), 9 (4), 9(6), 10(1-A), Rule 18 of PCPNDT Act for not keeping mandatory records and for violation of Section 5 (2), 6 and Rule 18 for communicating the sex of the Foetus with woman and her relatives. The gynecologist who performed an abortion has been booked for female foeticide under Rule 18 (X). As mentioned earlier, this is probably the first time authorities booked all the participants of the heinous act of female foeticide. The incident highlights the importance of proper documentation from the doctors. It also suggests that authorities need to take stern action against all the participants, especially the persons who coerce the doctors for participating in such criminal acts. Source: TNN

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Copyright 2015 © Docplexus Online Services Pvt LtdTNN | Mar 22, 2015, 04.35 AM IST
SURAT: In a first in Gujarat, a case of violation of the Pre-Conception and Pre-Natal Diagnostic Techniques (PCPNDT) Act was filed against a mother — Swati Dinesh Patil, resident of Nandurbar in Maharashtra — and her sister-in-law for sex determination of her foetus in Surat on Saturday. Until now, only doctors have been booked for PCPNDT violations in the state.

The FIR accusing a parent and family for PCPNDT violation is the fallout of the crackdown in an interstate sex determination racket being run by a homeopath doctor in Pandersara area.

Ramesh Kapadia, a quack, is a history-sheeter. "There are two PCPNDT violation cases pending against Kapadia in Gujarat high court. We have seized a mobile-sized sonography machine from him which he had hid in a helmet. The sonography was to be done in a flat. Such hush-hush operations indicate that the rot has set deep in society," said Dr Megha Mehta, chief district health officer (CDHO) Surat.

Dr Mehta said the operation has exposed a racket being run by an agent identified as Samadhan in Nandurbar who had tied up with Dr Kapadia and had sent women from Maharashtra for sex determination.
Probably for the first time, a patient from Pune has been booked under PCPNDT Act along with her mother, husband, and two gynecologists who allegedly aided the woman in an abortion of her own unborn female child. All of them were booked after an investigation which lasted for about 6 months. We have often seen radiologists and gynecologists being targeted indiscriminately by the government authorities under PCPNDT act. However, probably for the first time, the mother of two, who also is a lawyer by profession has been charged under PCPNDT act. The incident took place last year in Pune. An informant lodged a complaint with the police commissioner against the lawyer woman last year on August 19. The complaint was sent to local civic administration (Pune Municipal Corporation) for further legal action. After a long investigation, the authorities found that there was a substance in the complaint. The authorities investigated the documents which were seized and recorded the statements of various people as a part of an investigation. The qualified members from medical community were consulted which found that the foetus was normal and there was no evidence of bleeding or placental abnormality from USG which would warrant an abortion. The investigators also found that hospital sent the death information form to the municipal corporation on 23 June 2015, which mentioned the sex of the foetus as ‘female’. The medical records also showed that woman, who is a mother of two girls, frequently visited the alleged hospital for the treatment during the entire pregnancy. The abortion of the foetus was carried out on 23 June 2015 by one of the gynecologists. The woman was accompanied by her mother and the husband for the procedure. The case has been filed in the Judicial Magistrate First Class Court, Shivajinagar, Pune this year, alleging the violation of PCPNDT act 1994 and Rules 1996. The woman who is a practicing lawyer, is booked under 4(2), 6(B), 23 (3), Rule 18 (i), 18 (iii) and 18 (X) for not giving mandatory declaration under Rule 10 (1-A) and is liable for 3 years of imprisonment and/or ₹ 50,000 in fine. Mother and the husband of the woman have been booked for violating (2), 6(B), 23 (3), Rule 18 (i), 18 (iii) and 18 (X) for participating in sex determination and foeticide. The woman gynecologist (also the owner of hospital) is booked for violation of Section 4(3), 5,6,29 Rule 9(1), 9 (4), 9(6), 10(1-A), Rule 18 of PCPNDT Act for not keeping mandatory records and for violation of Section 5 (2), 6 and Rule 18 for communicating the sex of the Foetus with woman and her relatives. The gynecologist who performed an abortion has been booked for female foeticide under Rule 18 (X). As mentioned earlier, this is probably the first time authorities booked all the participants of the heinous act of female foeticide. The incident highlights the importance of proper documentation from the doctors. It also suggests that authorities need to take stern action against all the participants, especially the persons who coerce the doctors for participating in such criminal acts. Source: TNN

Read more at: http://www.docplexus.in/news/ab8e01d2-4297-49c3-a459-6319322b7f44/lawyer-mother-booked-under-pcpndt-act?utm_term=Email-Digest-0-morn&utm_campaign=Email-Digest&utm_medium=Email&utm_source=Docplexus.in&utm_content=CTA
Copyright 2015 © Docplexus Online Services Pvt Ltd

Evidence Suggests Zika Virus Can Cross Placental Barrier, But Microcephaly Link Remains Unclear

NEW YORK -- February 17, 2016 -- Zika virus has been detected in the amniotic fluid of 2 pregnant women whose foetuses had been diagnosed with microcephaly, according to a study published today in The Lancet Infectious Diseases.
The report suggests that Zika virus can cross the placental barrier, but does not prove that the virus causes microcephaly, as more research is needed to understand the link.
Researchers also analysed the whole genome of the virus found in the 2 pregnant women and confirmed that the virus is genetically related to the strain identified during an outbreak of Zika virus in French Polynesia in 2013.
“Previous studies have identified Zika virus in the saliva, breast milk, and urine of mothers and their newborn babies, after having given birth,” said lead author Ana de Filippis, MD, Oswaldo Cruz Institute in Rio de Janeiro, Rio de Janeiro, Brazil. “This study reports details of the Zika virus being identified directly in the amniotic fluid of a woman during her pregnancy, suggesting that the virus could cross the placental barrier and potentially infect the foetus.”
“This study cannot determine whether the Zika virus identified in these 2 cases was the cause of microcephaly in the babies,” she noted. “Until we understand the biological mechanism linking Zika virus to microcephaly we cannot be certain that one causes the other, and further research is urgently needed.”
The number of reported cases of newborn babies with microcephaly in Brazil in 2015 has increased 20-fold compared with previous years. At the same time, Brazil has reported a high number of Zika virus infections, leading to speculation that the two may be linked. Microcephaly has previously been linked to a range of factors including genetic disorders, drug or chemical intoxication, maternal malnutrition and infections with viruses or bacteria that can cross the placental barrier such as herpes, HIV, or some mosquito borne viruses such as chikungunya.
Dr. de Filippis and colleagues investigated the case of 2 women, aged 27 and 35 years, from Paraiba, Brazil. Both women presented with symptoms of Zika virus infection including fever, muscle pain, and a rash during their first trimester of pregnancy. Ultrasounds taken at approximately 22 weeks of pregnancy confirmed the foetuses had microcephaly.
Samples of amniotic fluid were taken at 28 weeks of pregnancy and analysed for potential infections. Both patients tested negative for dengue virus, chikungunya virus, and other infections such as HIV, syphilis, and herpes. Although the women’s blood and urine samples tested negative for Zika virus, their amniotic fluid tested positive for Zika virus genome and Zika antibodies. The amniotic fluid was analysed using metagenomic analysis, which allows for detection of any microorganism that could be present in the samples, but only Zika virus genome was found. The RNA of the 2 Zika virus samples was then compared with samples from previous outbreaks, and was found to be genetically related to the strain identified in French Polynesia in 2013.
In an accompanying commentary, Didier Musso, MD, Institut Louis Malarde, Tahiti, French Polynesia, wrote: “Even if all these data strongly suggest that Zika virus can cause microcephaly, the number of microcephaly cases related to Zika virus is still unknown. The next step will be to do case-control studies to estimate the potential risk of microcephaly after Zika virus infection during pregnancy, other fetal or neonatal complications, and long-term outcomes for infected symptomatic and asymptomatic neonates.”
SOURCE: The Lancet Infectious Diseases

Saturday, February 13, 2016

Pregnant women and Zika exposure: An update from CDC at an ad-hoc SMFM meeting

An ad-hoc session was held at the Society for Maternal-Fetal Medicine (SMFM) 36th Annual Pregnancy Meeting to share knowledge and discuss clinical best practices for optimizing maternal and perinatal health in the face of the recent Zika virusepidemic. 
Zika is a mosquito-borne single-stranded RNA Flavivirus, related to dengue virus. According to the CDC, only 1 in 5 people infected with Zika virus will become symptomatic. Characteristic clinical findings are an acute onset of fever with maculopapular rash, arthralgias, or conjunctivitis, usually within 1-2 weeks of infection.Other reported symptoms include a headache or myalgias. The illness is usually mild, with symptoms lasting for several days to a week. The actual Zika viral infection rate, incidence of maternal-fetal transmission, immune response, and any causal relationship to fetal microcephaly, abnormal brain development, or other adverse pregnancy outcome, are not currently known. Moreover, the CDC is uncertain on the sensitivity and specificity of currently available serologic testing (IgM, no IgG testing available). Current countries with reported active Zika virus transmission are shown in Figure 1, although CDC cautions that this map is routinely updated and should be rechecked frequently.
FIGURE 1: Countries with active Zika virus transmission [Source: CDC.gov]
Current guidelines call for at least baseline sonographic screening for fetal anomalies in general and for head and brain development specifically for pregnant women with exposure in Zika-endemic areas. Along with the potential need to discuss alternative differential diagnoses to explain any reported symptoms or findings, it is prudent and recommended to refer patients with concerns about Zika exposure or Zika-associated fetal issues to an MFM subspecialist with specific knowledge in this area whenever feasible. Subspecialists will then work directly with local and state health departments to coordinate testing and interpretation of results. A listing of state and territorial health departments can be found at http://www.cdc.gov/mmwr/international/relres.html. Zika testing currently is being performed almost exclusively at the CDC, but with the approval of a local health authority, many states are actively developing programs for screening and testing exposed pregnant women on a more local level.
Appropriate clinical scenarios requiring serum testing are listed below in the case studies. When sent, Zika serology IgM testing will be the most commonly run assay, with results reported as a titer, interpreted as “likely positive,” “inconclusive,” or “likely negative.” If a patient has been symptomatic in the preceding week (and only then), Zika RNA testing by reverse-transcriptase PCR (RT-PCR) will be performed. This emphasizes the importance of taking and providing a detailed travel and symptom history to the lab performing the testing. The sensitivity of the IgM assay is currently unknown and is being evaluated. This serum sample should also be tested for other common flaviviruses endemic to the area, such as dengue and chikungunya, but these tests must be ordered separately by the provider through commercial labs. A history should be obtained for prior exposure (vaccination or infection) to dengue, yellow fever, Japanese encephalitis or West Nile viruses, as these antibodies may cross-react with Zika testing. A positive Zika virus IgM should have a confirmatory neutralizing antibody titer ≥4-fold higher than dengue virus-neutralizing antibody titers in serum by plaque-reduction neutralization testing. Testing would be considered inconclusive if Zika virus-neutralizing antibody titers are < 4-fold higher than dengue virus-neutralizing antibody titers.

Tuesday, February 9, 2016

Sleep Deficits in Pregnancy Linked to Gestational Weight Gain

ATLANTA -- February 8, 2016 -- Too much or too little sleep in pregnancy is associated with gestational weight gain, which may help explain the link between poor sleep and poor outcomes in pregnancy, researchers said here on February 4 at The Pregnancy Meeting, the 2016 Annual Meeting of the Society for Maternal-Fetal Medicine (SMFM).
“We know that poor sleep in pregnancy has been linked to adverse pregnancy outcomes,” said Francesca Facco, MD, Magee-Women’s Research Institute at the University of Pittsburgh, Pittsburgh, Pennsylvania. “Our findings provide a potential mechanism for poor sleep in pregnancy and adverse outcomes.”
With previous studies linking poor sleep with weight gain and obesity in non-pregnant women, Dr. Facco and colleagues evaluated women enrolled in the Nulliparous Pregnancy Outcomes Study Monitoring Mothers-to-Be (nuMoM2b) study.
Women were recruited to wear an actigraph to record objective sleep activity for 7 consecutive days at 16 to 20 weeks of pregnancy.
Those with gestational diabetes and chronic hypertension were excluded.
In evaluating the actigraphy results and weight data available for 751 of the women, the researchers found the majority of women (74.8%) had sleep duration between 7 and <9 2.1="" 5.2="" and="" had="" hours="" night="" per="" while="">9 hours of sleep duration per night.
Groups with the smallest and largest weight gain were defined by Z scores of <-1 and="">+1.
In looking at gestational weight gain, calculated according to self-reported pre-pregnancy weight and weight recorded at 22 to 29 weeks and the last weight prior to delivery, the authors found large gestational weight gain (Z>+1) was less frequent with increases in sleep duration, while women with the shortest sleep duration (<6 and="" hours="" longest="">9 hours) had the highest rates of small gestational weight gain (Z<-1 p=""> The differences were most significant for weight gain at visit 2 (22 weeks; P < .0001) and visit 3 (P = .04), and they were significant to the degree for the last week prior to delivery (P = .05).
“Our data suggests that both short and long sleep duration in pregnancy are associated with gestational weight gain,” the authors wrote in their presentation. “Poor sleep in pregnancy has been linked to adverse pregnancy outcomes, and our findings provide one potential mechanism for this association.”
[Presentation title: Short and Long Sleep Durations in Pregnancy Are Associated With Extremes of Gestational Weight Gain. Abstract 33]

CDC Adds New Zika Warning for Pregnant Women and Their Sex Partners.

Women should not have sex while pregnant if male partners have visited or live in Zika-affected areas, agency says

FRIDAY, Feb. 5, 2016 (HealthDay News) -- Pregnant women with a male sexual partner who has traveled to, or lives in, an area affected by active Zika virus transmission should refrain from sex or use condoms during sex until the pregnancy is over, the U.S. Centers for Disease Control and Prevention advised on Thursday.
The CDC said the precaution is in place "until we know more" about the dangers of sexual transmission of the mosquito-borne virus, which is linked to thousands of cases of microcephaly in newborns in Brazil.
Speaking at a Friday morning news conference, CDC director Dr Tom Frieden also said the agency is investigating Brazilian research that detected Zika virus in patients' saliva and urine. At this point, however, the CDC's guidance to pregnant women does not include anything about kissing, he said.
"We're not aware of any prior mosquito-borne disease associated with such a potentially devastating birth outcome on a scale anything like appears to be occurring with Zika in Brazil," Frieden added.
"Because this phenomenon is so new, we are quite literally discovering more about it each and every day," he said.
"Because it's new and can be so severe, it can be scary, especially for women who are pregnant or considering pregnancy. There's no doubt that over the coming months many more travelers will return to the United States with Zika infection. Some of them will be pregnant women," Frieden said.
In the new advisory, the CDC added two new countries, Jamaica and Tonga, to its travel alert list of nations that pregnant women should avoid due to ongoing Zika virus transmission.
While the Zika epidemic first surfaced in Brazil last spring, Zika virus has since spread to 30 countries and territories in South and Central America and the Caribbean. Though a cause-and-effect link has not been proven, many public health experts fear the virus can cause microcephaly, a condition that causes babies to be born with permanent brain damage and very small heads.
On Tuesday, local health officials in Texas confirmed a case of Zika virus infection that was transmitted by sex, and not by the bite of a mosquito.
The Dallas County Health and Human Services Department said that an unidentified patient had become infected with the Zika virus after having sex with an individual who had returned from Venezuela, one of the Latin American countries where Zika is circulating.
Scientists have suspected that Zika could be transmitted sexually, and there have been scattered reports of similar occurrences in recent years.
If research proves that the virus can be spread through sex, it could complicate efforts to contain infections from the virus, which health officials have said is "spreading explosively" across South and Central America.
Ashley Thomas Martino is an assistant professor of pharmaceutical sciences at St. John's University, in New York City, who teaches infectious disease.
"We are dealing with an emerging strain of this virus. Zika is not new -- it has been around since the 1950s -- but this strain is showing that it can be transmitted from the mother to the developing fetus," he said. "So, the occurrence of sexual transmission may be new, but it's not that surprising given that we're dealing with a new strain of this virus."
Martino added that "most cases will be transmitted via mosquito, and this form of sexual transmission is likely to be a rare occurrence of infection."
The blood supply is also being monitored closely. The American Red Cross on Wednesday asked potential blood donors who have traveled to areas where Zika infection is active to wait 28 days before giving blood.
The chances of Zika-infected blood donations remain extremely low in the United States, Dr. Susan Stramer, vice president of scientific affairs at the American Red Cross, said in a statement
"The Red Cross continues to use safety measures to protect the blood supply from Zika and other mosquito-borne viruses," she said.
On Tuesday, the World Health Organization (WHO) declared the Zika virus a global health threat, based on the suspicion that the virus may be to blame for thousands of birth defects in Brazil in the past year.
Dr. Margaret Chan, director general of the WHO, said Monday that the explosive growth of microcephaly cases in Brazil constitutes an "extraordinary event and a public health threat to other parts of the world."
Chan made her remarks during an emergency meeting at the U.N. health agency's headquarters in Geneva, Switzerland, to assess what is known about the Zika virus and its potential relation to the surge of birth defects in Brazil.
The WHO estimates there could be up to 4 million cases of Zika in the Americas in the next year. However, no recommendations were made Monday to restrict travel or trade, the Associated Press reported.
U.S. health officials have said it's unlikely that the Zika virus will cause a widespread threat here, but some infections are likely to occur.
The Zika virus was first identified in Uganda in 1947, and until last year was not thought to pose serious health risks. In fact, approximately 80 percent of people who become infected never experience symptoms.
But the increase of cases and birth defects in Brazil in the past year -- suspected to exceed more than 4,100 -- has prompted health officials to warn pregnant women or those thinking of becoming pregnant to take precautions or consider delaying pregnancy.
"It is important to understand, there are several measures pregnant women can take," Chan said, the AP reported. "If you can delay travel and it does not affect your other family commitments, it is something they can consider.
"If they need to travel, they can get advice from their physician and take personal protective measures, like wearing long sleeves and shirts and pants and use mosquito repellent," she said.
There have been no outbreaks of Zika virus in the United States so far. But, limited U.S. outbreaks are "possible" and "even likely" given that the same sort of aggressive, day-biting mosquito that spreads Zika is present in the southern United States, said Dr. Anne Schuchat, principal deputy director of the CDC.
However, Schuchat emphasized that the main health concern at this time is for pregnant women who are exposed to the virus.
Although health officials view some U.S. cases of Zika infection as likely, particularly in southern states, the United States enjoys certain advantages that should keep such an outbreak limited to a small area, Schuchat said.
Urban areas in the United States are less congested than they are in other countries of the Americas, making it more difficult for mosquitoes to spread disease hopping from one person to the next, she said.
Also, people in the United States are more likely to have their windows shut, thanks to air conditioning, or to have screens on open windows, which keep mosquitoes from invading their homes, she added.
SOURCES: Feb. 5, 2016 news conference with Dr. Tom Frieden, director, U.S. Centers for Disease Control and Prevention; Feb. 4, 2016, statement, U.S. Centers for Disease Control and Prevention; Feb. 3, 2016, statement, American Red Cross; Feb. 2, 2016, statement, Dallas County Health and Human Services; Feb. 1, 2016, statement, Margaret Chan, M.D., director general, World Health Organization, Geneva, Switzerland; Anne Schuchat, M.D., principal deputy director, U.S. Centers for Disease Control and Prevention; Ashley Thomas Martino, Ph.D., assistant professor of pharmaceutical sciences, St. John's University, New York City

Sunday, February 7, 2016

Antenatal Betamethasone for Women at Risk for Late Preterm Delivery.

Background

Infants who are born at 34 to 36 weeks of gestation (late preterm) are at greater risk for adverse respiratory and other outcomes than those born at 37 weeks of gestation or later. It is not known whether betamethasone administered to women at risk for late preterm delivery decreases the risks of neonatal morbidities.

Methods

We conducted a multicenter, randomized trial involving women with a singleton pregnancy at 34 weeks 0 days to 36 weeks 5 days of gestation who were at high risk for delivery during the late preterm period (up to 36 weeks 6 days). The participants were assigned to receive two injections of betamethasone or matching placebo 24 hours apart. The primary outcome was a neonatal composite of treatment in the first 72 hours (the use of continuous positive airway pressure or high-flow nasal cannula for at least 2 hours, supplemental oxygen with a fraction of inspired oxygen of at least 0.30 for at least 4 hours, extracorporeal membrane oxygenation, or mechanical ventilation) or stillbirth or neonatal death within 72 hours after delivery.

Results

The primary outcome occurred in 165 of 1427 infants (11.6%) in the betamethasone group and 202 of 1400 (14.4%) in the placebo group (relative risk in the betamethasone group, 0.80; 95% confidence interval [CI], 0.66 to 0.97; P=0.02). Severe respiratory complications, transient tachypnea of the newborn, surfactant use, and bronchopulmonary dysplasia also occurred significantly less frequently in the betamethasone group. There were no significant between-group differences in the incidence of chorioamnionitis or neonatal sepsis. Neonatal hypoglycemia was more common in the betamethasone group than in the placebo group (24.0% vs. 15.0%; relative risk, 1.60; 95% CI, 1.37 to 1.87; P<0 .001="" p="">

Conclusions

Administration of betamethasone to women at risk for late preterm delivery significantly reduced the rate of neonatal respiratory complications.
(Funded by the National Heart, Lung, and Blood Institute and the Eunice Kennedy Shriver National Institute of Child Health and Human Development; ClinicalTrials.gov number, NCT01222247.)

Saturday, February 6, 2016

Zika in pregnancy:- CDC directives for US citizen

CDC directives for US citizen
Testing pregnant women who have a clinical illness consistent with Zika virus disease during or within 2 weeks of travel to areas with ongoing viral transmission is still recommended, as stated in the CDC's recommendations from January 19, 2016. They also recommend that health officials should decide when to implement testing of asymptomatic pregnant women based on information about levels of Zika virus transmission and laboratory capacity.
Discussions of pregnancy intention and timing should be initiated by health care providers with women of reproductive age (15 to 44 years) in the context of risks related to Zika virus infection. Due to the potential risks of maternal Zika virus infection, pregnant women whose male partners have or are at risk for Zika virus infection should consider using condoms or be abstinent.
The guidelines further reiterate how pregnant women, who live in areas of ongoing transmission, are at risk for infection throughout their pregnancy. With no vaccine or medication currently available to prevent the infection, the CDC advises health care providers and residents to strictly follow steps to avoid mosquito bites. Preventive efforts include wearing long-sleeved shirts, pants, permethrin-treated clothing, and using U.S. Environmental Protection Agency (EPA)-registered insect repellents.
Zika virus infection is associated with an increased risk for congenital microcephaly and other abnormalities of the brain and eye in newborns. On February 1, the World Health Organization (WHO) declared the virus a Public Health Emergency of International Concern. Recommendations will continue to be updated as more information becomes avaiable.

Does Betamethasone Reduce Neonatal Complications for Women at Risk of Late Preterm Delivery?

HealthDay News — For women at risk for late preterm delivery, betamethasone administration reduces the rate of neonatal respiratory complications, according to a study published online Feb. 4 in the New England Journal of Medicine. The research was published to coincide with the annual meeting of the Society for Maternal-Fetal Medicine, held from February 1 to 6 in Atlanta.
Cynthia Gyamfi-Bannerman, MD, from the Columbia University Medical Center in New York City, and colleagues conducted a multicenter, randomized trial involving women with a singleton pregnancy who were at high risk for delivery during the late preterm period (34 to 36 weeks of gestation). Participants were randomized to receive two injections of betamethasone or matching placebo 24 hours apart.
The researchers found that the primary outcome (a neonatal composite of treatment, stillbirth, or neonatal death within 72 hours after delivery) occurred in 11.6% of 1427 infants and in 14.4% of 1,400 infants in the betamethasone and placebo groups, respectively (relative risk in the betamethasone group, 0.80; P = 0.02). In the betamethasone group, severe respiratory complications, transient tachypnea of the newborn, surfactant use, and bronchopulmonary dysplasia occurred significantly less frequently. The incidence of chorioamnionitis and neonatal sepsis did not differ significantly between the groups. The betamethasone group more often had neonatal hypoglycemia (24.0 versus 15%; relative risk, 1.60; P < 0.001).
"Administration of betamethasone to women at risk for late preterm delivery significantly reduced the rate of neonatal respiratory complications,"

Friday, February 5, 2016

Delayed Umbilical Cord Clamping in the 21st Century: Indications for Practice.

Health care providers have debated the timing of umbilical cord clamping since the days of Aristotle. Delayed cord clamping was the mainstay of practice until about the 1950s when it was changed to immediate clamping on the basis of a series of blood volume studies combined with the introduction of active management of the third stage of labor. However, in recent years, several systematic reviews advise that delayed cord clamping should be used in all births for at least 30 to 60 seconds.

PURPOSE:

The purpose of this article is to discuss the physiology of umbilical cord clamping, the potential benefits and adverse effects of delayed cord clamping, and how this affects the advanced practice nurse.

SEARCH STRATEGY:

A search of PubMed, Cochrane Reviews, and Clinical Key was used to find relevant research on the topic of umbilical cord clamping.

RESULTS:

Potential benefits of delayed cord clamping include decreased frequency of iron-deficiency anemia in the first year of life with improved neurodevelopmental outcomes in term infants, reduced need for blood transfusions, possible autologous transfusion of stem cells, and a decreased incidence of intraventricular hemorrhage. Apprehension exists regarding the feasibility of the practice as well as the potential hindrance of immediate resuscitation.

IMPLICATIONS FOR PRACTICE:

There is a need to begin to look for populations for which delayed cord clamping can be implemented.

IMPLICATIONS FOR FUTURE RESEARCH:

Recommendations are inconsistent on the patient population and timing; therefore, further studies are needed to understand the multiple variables that affect timing of umbilical cord clamping.

 Adv Neonatal Care. 2016 Feb;16(1):68-73. doi: 10.1097/ANC.0000000000000247.

ZIKA Education material for community

Zika virus is spread by black mosquitoes (Aedes aegypti or Aedes albopictus) with bands of white dots that look like white stripes. Their legs are also striped. These are the same mosquitos that can carry dengue, chikungunya, and yellow fever viruses. These mosquitos usually bite during the day, especially in the early morning and late afternoon. When Zika virus appears in an area for the first time, it can spread very quickly.
Zika virus causes a mild fever, rash, and body aches, usually for a few days only. Many people who get it develop no signs. It can be hard to tell which virus a person has if Zika, dengue, and chikungunya are all present in your region. Zika can be very dangerous to a baby in the womb if the mother gets Zika during pregnancy.

Zika virus and pregnancy

It is possible that Zika can be dangerous for a baby growing in the womb. In Brazil, following an outbreak of Zika, some babies were born with a serious condition called microcephaly, where the baby’s head is too small. Babies with microcephaly may die at birth or may live for many years but have problems developing physically and mentally. Because of this, all women and especially women who might be pregnant should try to prevent mosquito bites by covering up with clothing, using mosquito repellents, and keeping mosquitoes away by using screens and bed nets in the home.
If you are thinking about getting pregnant, it is a good idea to wait until after Zika is no longer affecting people in your community. Ensuring that birth control is made accessible to all women is an important way to limit harm from the Zika virus.
Signs of Zikainfection
  • Fever, rash, joint pain, and irritated or red eyes ("pink eye" or conjunctivitis) are most common.
  • Muscle pain and headache can also be signs.
Zika is usually mild and lasts just a few days or up to 1 week. Usually a person with Zika virus is not sick enough to need to go to a hospital.
Malaria, dengue, chikungunya, and other illnesses can have similar signs as Zika. Except for malaria, tests can be slow, expensive, and difficult to find. Health officials in your area should have information on whether one or more of these illnesses are in your region and if tests are available.

Treatment
There is no medicine to treat Zika virus, and no vaccine to prevent it. Zika can be treated at home with bed rest, drinking plenty of fluids, and taking acetaminophen (paracetamol) to reduce pain and fever. In case the person has dengue, and not Zika, using acetaminophen is safer than aspirin or ibuprofen, which are dangerous for people with dengue. If a woman might be pregnant, aspirin and ibuprofen could be harmful to her baby but acetaminophen is safe.
When you are sick, a mosquito can bite you and spread the virus to other people it bites. That is why it is good prevention for the community to protect a sick person from getting any new mosquito bites. Use a bed net while in bed and stay away from water sources (like rivers, wells, or water pumps) early in the morning or late in the day when these mosquitos bite most.

Reasons to see a health worker

Zika can be treated at home but seeing a health worker is especially important when there is:
  • very high fever (40°C/104°F).
  • fever followed by unexplained bleeding from the skin or gums (this is an emergency).
  • illness in a baby.
  • illness in someone elderly or with serious health problems including high blood pressure or heart problems.
  • severe aches that continue longer than 2 weeks.
Informing local health workers and health officials about who is sick can help them know when it is urgent to take community-wide measures to stop the illness from spreading.

How mosquitoes spread disease

You can stop illnesses carried by mosquitoes by preventing mosquito bites and preventing mosquitoes from breeding in the home and in the community.

Prevent mosquito bites

Unlike the malaria mosquito, the mosquitoes carrying Zika bite mostly during the day. These mosquitoes usually stay in shady, dark places, such as under tables or beds, or in corners. You can avoid mosquito bites:
  • Wear clothes that completely cover the arms, legs, neck, and head (long sleeves, pants, and skirts, and a head covering).
  • Use natural repellents like citronella, neem oil, or basil leaf. Or use chemical repellents that have one of these ingredients: DEET, Picardin (KBR 3023, icaridin), PMD and other oil of lemon eucalyptus compounds, or IR3535. Repellents are especially important for children because they can prevent mosquito bites even when other preventive steps are not taken, but read the label carefully to make sure the product is safe for children. The label will also say how often to reapply. Usually repellent needs to be reapplied every few hours, but some last less time.
  • Only use mosquito coils until you can find a better repellent. The smoke from the mosquito coils can harm your breathing.
  • Use screens on windows and doors. Repair or patch any holes.
  • The moving air from a fan can keep mosquitos away.
  • Use bed nets. Tuck the edges of the nets under the bed or sleeping mat so there are no openings.

Bed nets are especially helpful against the malaria mosquito that bites at night, but they also help prevent Zika for small children or others who sleep during the day. Bed nets will also keep those who are already ill from being bitten by a mosquito that could then give the illness to others. Mosquito netting and bed nets treated with insecticide are best. To be effective, bed nets must be re-treated every 6 to 12 months. Use a net when sleeping outdoors.

Prevent mosquitoes from breeding

The mosquitoes that spread Zika, dengue, and chikungunya breed in standing water. A mosquito will lay eggs in even a shallow dish of water where they will hatch in about 7 days. By getting rid of standing water once a week, mosquito breeding is interrupted because their eggs do not hatch to spread disease. To prevent mosquitoes from breeding:
  • Outside your home, get rid of places where water collects (standing water) such as old car tires, flower pots, oil drums, ditches, and even small containers and bottle caps. Do this at least once a week or after it rains.
  • Inside the house, frequently change the water in flower vases and water dishes for animals. Unless containers are scrubbed clean, mosquito eggs can stick to the sides of the containers where they can live for months until there is water to make them hatch.
  • Tightly cover water storage containers so mosquitoes can’t get inside to lay eggs. For containers, barrels, or water tanks with no lids, use screens or wire mesh with holes too small for a mosquito to get in, or cover with plastic sheeting and tie in place.     

Communities can prevent mosquito illnesses

The community can help elderly people, people with disabilities, or families without enough money to get the supplies or make the changes they need to avoid mosquito bites. Help your neighbors keep their yards and homes free of standing water to prevent mosquitoes from breeding (See above). As long as mosquitoes find a place to breed, they can infect everyone in the community. That is why community-wide prevention efforts are so important.
Roadways and anywhere else water collects need attention to stop mosquitoes from breeding. Keeping natural waterways and rain water moving and flowing will keep water from collecting. Manage land so water soaks into the ground or runs off into streams instead of collecting in areas where mosquitoes can breed. Protect watersheds so water will keep flowing. Don’t let water pool on the ground, collect in trash dumps or vacant lots, or allow streams to be blocked by eroded soil, leaves, or other debris.
        
                    Source Hespa.Health

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