Taking the contraceptive pill, particularly for
seven or more consecutive years, is linked to a lowered risk of developing
rheumatoid arthritis, finds research published online in the Annals of the
Rheumatic Diseases.
But no significant link was found for
breastfeeding a practice that has been associated with a protective effect
after accounting for various potentially influential factors, the findings
show.
According to a new study
by Karolinska Institute in Stockholm, Sweden, and published in the
journal Annals of the Rheumatic Diseases it has been found that women
who take the oral contraceptive pill are protected from going on to
develop arthritis in later life. This has led scientists to believe
hormonal and reproductive factors may contribute to the underlying cause.
Rheumatoid arthritis
an autoimmune systemic disease which mainly attacks the joints,
most often the knees, hands, and wrists but it can also affect the lungs,
heart, eyes, and other parts of the body. It develops between the ages of
40 and 50 and affects up to 1 percent of people
worldwide.It occurs when the body’s immune system targets joints such as the
wrists and ankles, causing painful swelling, and is twice as common in women as
it is in men.
Researchers believe that hormonal
changes prompted by the pill may decrease the risk of suffering from the
painful disease.In the study it was found that using the common
contraceptive method for seven or more years was associated with a 19 per cent
lower chance of developing rheumatoid arthritis.Women who had stopped
using the pill still appeared to benefit from a protective effect, enjoying a
13 per cent lower risk of the condition.The data for the study was drawn
from 2,809 women with the disease and compared it with the medical
records of 5,312 women randomly selected from the general population.
The data from the Swedish Epidemiological Investigation of Rheumatoid
Arthritis (EIRA) included women aged 18 and above, living in a defined area of
Sweden between 1996 and 2014.
All participants had given blood samples, so the
researchers could check for a blood marker for rheumatoid
arthritis called anti-citrullinated protein antibodies (ACPAs).
It
was found that current use of contraceptive pill was linked to 15 percent
reduced risk, while past use was linked to 13 percent reduced risk.The
researchers suggest that there could be a “dose-response” effect: using oral
contraception for more than 7 years was linked to a 19 percent ler risk of
developing rheumatoid arthritis, even for women who tested negative for ACPAs.
In
this present study it was therefore concluded that women who had ever
used oral contraceptives had a significantly decreased risk of developing RA .
Although
a lower risk was also found among women who had breastfed at least one child,
this was not significant after potentially influential factors were accounted
for.
This
is an observational study so no firm conclusions can be drawn about cause and
effect, added to which the researchers were unable to glean any information
about the dose or type of oral contraceptive the women used.
But
the number of participants was large, and a wide range of potentially
influential factors was looked at, the researchers point out.