Leung TY et al. – After birth, resumption of iron chelation and bisphosphonates treatment is needed, and counselling on breast feeding and contraception should be given.
- Thalassaemia is the most common monogenetic disease worldwide.
- Antenatal screening is effective and simple, and accurate genetic prenatal diagnosis can be achieved in early gestation.
- Less invasive methods are feasible with ultrasound fetal assessment for alpha–thalassaemia, analysis of circulating fetal nucleic acid in maternal plasma, and pre–implantation genetic diagnosis.
- Women with thalassaemia major and intermedia are at risk of various maternal complications, such as cardiac failure, alloimmunisation, viral infection, thrombosis, endocrine and bone disturbances.
- Therefore, it is prudent to adhere to a standard management plan in this group of pregnant women.
- Close monitoring of the maternal and fetal condition during pregnancy is essential, and various treatments, such as blood transfusion or postpartum prophylaxis for thromboembolism, may be indicated.
- After birth, resumption of iron chelation and bisphosphonates treatment is needed, and counselling on breast feeding and contraception should be given.
No comments:
Post a Comment