LONDON (Reuters) Jul 03 - Two men with HIV have been off AIDS drugs
for several months after receiving stem-cell transplants for cancer that
appear to have cleared the virus from their bodies, researchers
reported on Wednesday.
Both patients, who were treated in Boston and had been on long-term drug therapy to control their HIV, received stem-cell transplants after developing lymphoma, a type of blood cancer.
Since the transplants, doctors have been unable to find any evidence of HIV infection, Timothy Henrich of Harvard Medical School and Brigham and Women's Hospital in Boston told an International AIDS Society conference in Kuala Lumpur.
While it is too early to say for sure that the virus has disappeared from their bodies altogether, one patient has now been off antiretroviral drug treatment for 15 weeks and the other for seven weeks.
Last July Dr. Henrich first reported that the two men had undetectable levels of HIV in their blood after their stem-cell treatment, but at that time they were still taking medicines to suppress HIV.
Using stem-cell therapy is not seen as a viable
option for widespread use, since it is extremely expensive, but the
latest cases could open new avenues for fighting the disease, which
infects about 34 million people worldwide.
The latest cases resemble that of Timothy Ray Brown, known as "the Berlin patient," who became the first person to be cured of HIV after receiving a bone marrow transplant for leukemia in 2007. There are, however, important differences.
While Brown's doctor used stem cells from a donor with a rare genetic mutation, known as CCR5 delta 32, which renders people virtually resistant to HIV, the two Boston patients received cells without this mutation.
"Dr. Henrich is charting new territory in HIV eradication research," Kevin Robert Frost, chief executive officer of the Foundation for AIDS Research, which funded the study, said in a statement.
The latest antiretroviral AIDS drugs can control HIV for decades. But many people still do not get therapy early enough, prompting the World Health Organization to call for faster roll-out of medicines after patients test positive.
Reuters Health Information
Both patients, who were treated in Boston and had been on long-term drug therapy to control their HIV, received stem-cell transplants after developing lymphoma, a type of blood cancer.
Since the transplants, doctors have been unable to find any evidence of HIV infection, Timothy Henrich of Harvard Medical School and Brigham and Women's Hospital in Boston told an International AIDS Society conference in Kuala Lumpur.
While it is too early to say for sure that the virus has disappeared from their bodies altogether, one patient has now been off antiretroviral drug treatment for 15 weeks and the other for seven weeks.
Last July Dr. Henrich first reported that the two men had undetectable levels of HIV in their blood after their stem-cell treatment, but at that time they were still taking medicines to suppress HIV.
The latest cases resemble that of Timothy Ray Brown, known as "the Berlin patient," who became the first person to be cured of HIV after receiving a bone marrow transplant for leukemia in 2007. There are, however, important differences.
While Brown's doctor used stem cells from a donor with a rare genetic mutation, known as CCR5 delta 32, which renders people virtually resistant to HIV, the two Boston patients received cells without this mutation.
"Dr. Henrich is charting new territory in HIV eradication research," Kevin Robert Frost, chief executive officer of the Foundation for AIDS Research, which funded the study, said in a statement.
The latest antiretroviral AIDS drugs can control HIV for decades. But many people still do not get therapy early enough, prompting the World Health Organization to call for faster roll-out of medicines after patients test positive.
Reuters Health Information
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