December 16, 2015
PROVIDENCE,
RI -- December 16, 2015 -- To prevent pre-eclampsia, new research
suggests that low-dose aspirin should be given prophylactically to all
women at high risk (those with diabetes or chronic hypertension) and any
woman with 2 or more moderate risk factors (including obesity, multiple
gestation, and advanced maternal age).
The findings are published in the December issue of the journal Obstetrics & Gynecology.
Erika Werner, MD, Division of Maternal-Fetal Medicine at Women & Infants Hospital of Rhode Island, and Brown University, Providence, Rhode Island, and colleagues developed a decision model to evaluate the risks, benefits, and costs of 4 different approaches to aspirin prophylaxis: no prophylaxis, prophylaxis per recommendations of the American College of Obstetricians and Gynecologists (ACOG), prophylaxis per the US Preventive Task Force (USPTF) recommendations, and universal prophylaxis for all women.
The estimated rate of pre-eclampsia would be 4.18% without prophylaxis compared with 4.17% with the College approach in which 0.35% (n = 14,000) of women receive aspirin, 3.83% with the USPTF approach in which 23.5% (n = 940,800) receive aspirin, and 3.81% with universal prophylaxis.
Compared with no prophylaxis, the USPTF approach is the most cost-beneficial in 79% of probabilistic simulations.
“Both the US Preventive Task Force approach and universal prophylaxis would reduce morbidity, save lives, and lower healthcare costs in the United States to a much greater degree than the approach currently recommended by ACOG,” the authors wrote.
SOURCE: Care New England
The findings are published in the December issue of the journal Obstetrics & Gynecology.
Erika Werner, MD, Division of Maternal-Fetal Medicine at Women & Infants Hospital of Rhode Island, and Brown University, Providence, Rhode Island, and colleagues developed a decision model to evaluate the risks, benefits, and costs of 4 different approaches to aspirin prophylaxis: no prophylaxis, prophylaxis per recommendations of the American College of Obstetricians and Gynecologists (ACOG), prophylaxis per the US Preventive Task Force (USPTF) recommendations, and universal prophylaxis for all women.
The estimated rate of pre-eclampsia would be 4.18% without prophylaxis compared with 4.17% with the College approach in which 0.35% (n = 14,000) of women receive aspirin, 3.83% with the USPTF approach in which 23.5% (n = 940,800) receive aspirin, and 3.81% with universal prophylaxis.
Compared with no prophylaxis, the USPTF approach is the most cost-beneficial in 79% of probabilistic simulations.
“Both the US Preventive Task Force approach and universal prophylaxis would reduce morbidity, save lives, and lower healthcare costs in the United States to a much greater degree than the approach currently recommended by ACOG,” the authors wrote.
SOURCE: Care New England
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