Even a single, low dose of fluconazole may increase miscarriage risk.

A nationwide cohort study in Denmark reports that pregnant women taking 1 or 2 fluconazole 150 mg doses from 7 through 22 weeks gestation may be at significantly higher risk of miscarriage.¹

The study informed a 2016 FDA Drug Safety Communication:

· Pregnant women and women trying to get pregnant should discuss alternative treatment options to fluconazole with their healthcare professionals2 · The FDA is reviewing the study results and other data before making a final recommendation.

CDC Guidelines on Vulvovaginal Candidiasis (VVC) state: Only topical azole therapies, applied for 7 days, are recommended for   use among pregnant women3                  References: 1. Mølgaard-Nielsen D, Svanström H, Melbye M, Hviid A, Pasternak B. Association between use of oral fluconazole during pregnancy and risk of spontaneous abortion and stillbirth. JAMA. 2016;315(1):58-67. 2. Lowes R. Low-dose fluconazole in pregnancy worries FDA. Available at: http://www.medscape.com/viewarticle/862447. Published April 26, 2016. Accessed August 26, 2017. 3. Centers for Disease Control and Prevention. Vulvovaginal candidiasis. Available at: http://www.cdc.gov/std/tg2015/candidiasis.htm. Updated June 4, 2015. Accessed August 26, 2017.