Here's what doctors need to know about this condition that affects all women
by Diana L. Bitner MD
There is a health condition that all women experience and is the
single most dramatic risk factor for heart disease, stroke, diabetes,
obesity, and osteoporosis. This health condition is well understood and
can be managed with evidence-based treatments.
However, this condition is rarely discussed, adequately screened, or
sufficiently treated. Women feel confused, ignored, and minimized when
they complain of symptoms leading up to and during the most burdensome
years. Many women are told "it is just a phase, (essentially) deal with
it" and even the most ardent brain thermostat gives up over time, and
hot flashes go away. Vasomotor symptoms act as alarm bells telling us
that cholesterol levels, blood sugars, and inflammatory markers are
rising, bone is wasting, and the corpus colosseum is shrinking.
But
since menopause might seem too murky and confusing, hormone treatment
too confusing and scary, and women being only 50% of the population, it
is often dismissed as something to be accepted like Tom Cruise telling
Brooke Shields on National TV that postpartum depression was in her mind
and she should exercise more.
Menopause needs to be seen for what it is -- the cessation of
ovarian function. Loss of estrogen causes metabolic derangement. There's
no controversy about that.
Menopause is an opportunity for the healthcare system to do the right
thing -- whether for a 16-year-old after life-saving chemotherapy, a
35-year-old after an unexpected BSO, or a 51-year-old experiencing
natural menopause and told her rising waistline, sleeplessness, and pain
with sex is natural and to "watch her diet."
The effects of loss of estrogen are lifelong. As healthcare
providers, I believe we are obligated to inform women of life-altering
irreversible changes, and best practices to alter their diet, exercise,
and other habits as well as perhaps consider hormone medication options
to mitigate physiologic changes.
A study that stands out in my mind showed that peritoneal fat cells
change their phenotype in menopausal women. With loss of estrogen, the
cells produce significant amounts of inflammatory agents such as CRP and
IL-6 versus the pre-menopause state. The KEEPS trial showed women
taking transdermal estrogen have less insulin resistance, and JoAnn
Manson at Harvard showed that women undergoing a BSO before age 45 had a
significant increase in risk for cardiovascular disease if not given
hormone replacement. These are just a few examples of the width and
breadth of data demonstrating how hot flashes are alarm bells for what
is happening under the surface.
In
the years of my uphill battle to develop a whole service line for
midlife and menopause in a large healthcare system, I have gained a
thorough understanding that even if a clinical program is a good idea,
buckets of money do not exist for implementation. I have learned that
clinical programs require strategy, planning, and a positive business
proforma. And, many champions must speak loudly for coveted dollars to
be invested.
In the process to help my healthcare system understand the
opportunity of menopause, I strategized for and got a meeting in the C
Suite with several system business leaders. In this meeting, a very well
respected executive, near retirement, leaned back in his chair,
steepled his fingers, asked me the question that had been a consistent
barrier for leadership: "Menopause Clinic? Isn't menopause just
something women have to deal with?"
Thank goodness he wanted open discussion of that question and I was
able to present the solutions we would be solving and the clinical as
well as business case for the program. The result of that meeting was
health system support, and I am forever grateful he listened and that
our Midlife and Menopause Health Services Clinic now exists.
Take Marcie (not her real name) as an example. She waited 3 months to
see me. Her chief complaint in EPIC was "menopause symptoms" and as I
reviewed her history, I saw she was 54, had never been pregnant, was 16
months from her last period, and had gained 12 pounds in the last 8
months.
Her prior physical with her PCP covered all the screening basics, but
the standardized form did not allude to menopause status or treatment
options. In the annual visit HPI there was mention of night sweats, and
in the plan was "refer to Midlife and Menopause." Victory No. 1, high
referral rate from our PCPs as a result of many "lunch-n-learns," and
happy patients.
I
walked in the room, laptop in hand, and sat down across from her. I
shook her hand, closed my computer, and asked, "what is hard?" She
quickly answered, "the fatigue, the fatigue is really hard." Her night
sweats started 1 year prior to her LMP and ever since, she had been
waking up tired and she felt moody. She also talked about how sex hurt,
and was no longer enjoyable. She used to initiate sex with her husband,
but now neither did because fear outweighed desire.
Over time as she felt worse, she exercised less, and ate more simple
carbs. Because of the weight gain, she felt unattractive to her husband,
and was frustrated every morning because her clothes did not fit.
Victory No. 2, she was sharing personal details, which would lay the
foundation for a trusting doctor-patient relationship.
I then took the driver's seat, opened my computer, and walked her
through a symptom inventory, including questions about sexual health as
well as lifestyle habits. I asked what she took in for each meal and
snack, and how much alcohol she consumed. I gained many data points,
which would allow for risk stratification, and help me understand
opportunity for risk-reducing change. We reviewed her medical history,
including potential risk factors such as DVT, which could preclude safe
use of hormone therapy. We discussed the components of sex drive, and
why her libido had changed. She visibly perked up and was involved.
Victory No. 3, potential partner in preventing her premature heart
attack.
After a pelvic exam that revealed low estrogen demonstrated by flat
rugae and a pH of 7.0, and tight tender pelvic floor muscles, she got
dressed, and we talked. I explained how her ovaries had stopped
producing estrogen, progesterone, and testosterone, and loss of these
hormones caused many of her symptoms. While she had minimal healthcare
knowledge and only a high school education, I saw a light bulb turn on
as I explained the physiology of where the hormones work on the brain,
skin, vagina, uterus, breast, and bones. I explained how triggers such
as sleep deprivation, weight gain, and a diet high in sugar could also
trigger symptoms. A tear rolled down her face as she said, "I am not
crazy?" Victory No. 4, the tear. Now, opportunity was palpable.
Next we discussed options for treatment, starting with lifestyle. I
have created a list of seven habits I call the SEEDS, or "Seven
Essential Elements of Daily Success" including water, vitamins, food
groups, fiber, exercise, sleep, and gratitude. We put together how the
habits could help, leading to a discussion of her barriers. Victory No.
5, starting her process to healthy change.
The
discussion about hormone replacement therapy ensued, and I informed her
of the basic findings of studies such as ELITE, WHI, KEEPS, NHS, and
Vital. I explained the likely benefits of HRT, how to take it, and
guidelines, giving the menopause.org website. She was a perfect
candidate to trial HRT, and chose to accept a prescription. Victory
No.6, a balanced discussion leaving her knowing there were hormone
medication options.
I then asked her to follow up in 3 months, and to have blood work
done, including an HbA1c and a DEXA bone density test. Because of her
not having children and a history of dense breasts, I offered her an
appointment at the high-risk breast clinic for advanced screening. Also,
because of her fatigue, I sent her to the preventive cardiologist, and
for her tight pelvic floor, to the Pelvic Floor Physical Therapist.
Victory No. 7. Total health understood, valuable healthcare resources
being utilized.
After 8 months, Marcie lost and kept off 20 pounds, worked to drop
her HbA1c from 6.1 to 5.5, and lowed her blood pressure and cholesterol.
She is happy on her 0.05 mg estrogen patch and micronized progesterone.
Her stress echo was negative, and she had only mild osteopenia. Her
fatigue was gone, her moods happy and coping skills improved, her
exercise regular, and she felt normal. Victory No. 8. Heart attack
prevented until age of 106 (dramatized, but you get my point).
Yes, menopause visits can be lengthy, and not well reimbursed. In a
Work Relative Value Unit (WRVU) based system, moving from an ob/gyn
salary to that of a card-carrying NAMS Certified Menopause Practitioner
is not the best personal financial move. However, the results of such
work is priceless. If more healthcare systems were to embrace mid-life
and menopause health as the front-line of wellness care for women,
engaged patients would flood the gates to join and everyone wins.
Menopause is an opportunity, not a just a condition or group of
symptoms to be tolerated. Menopause needs to be embraced for the gift it
gives us, a chance to save lives and reduce preventable illness