HealthDay News — New risk factors have been identified for varicose
vein disease, including height, according to a study published online
September 24 in Circulation.
Eri Fukaya, MD, PhD, from the Stanford University School of Medicine in California, and colleagues applied machine learning to agnostically search for varicose vein risk factors in a cohort of 493,519 individuals in the UK Biobank. Predictors were further studied for 2441 incident events. A genome-wide association study of varicose veins was also performed among 337,536 unrelated individuals (9577 cases) of white British descent.
The researchers found that several known risk factors were confirmed with machine learning (age, sex, obesity, pregnancy, history of deep vein thrombosis), and several new risk factors were identified, including height. Greater height remained independently associated with varicose veins after adjustment for traditional risk factors (hazard ratio for upper versus lower quartile, 1.74). Thirty new genome-wide significant loci were identified in a genome-wide association study, identifying pathways involved in vascular development and skeletal/limb biology. There was evidence that increased height was causally related to varicose veins in Mendelian randomization analysis (inverse-variance weighted: odds ratio, 1.26).
Eri Fukaya, MD, PhD, from the Stanford University School of Medicine in California, and colleagues applied machine learning to agnostically search for varicose vein risk factors in a cohort of 493,519 individuals in the UK Biobank. Predictors were further studied for 2441 incident events. A genome-wide association study of varicose veins was also performed among 337,536 unrelated individuals (9577 cases) of white British descent.
The researchers found that several known risk factors were confirmed with machine learning (age, sex, obesity, pregnancy, history of deep vein thrombosis), and several new risk factors were identified, including height. Greater height remained independently associated with varicose veins after adjustment for traditional risk factors (hazard ratio for upper versus lower quartile, 1.74). Thirty new genome-wide significant loci were identified in a genome-wide association study, identifying pathways involved in vascular development and skeletal/limb biology. There was evidence that increased height was causally related to varicose veins in Mendelian randomization analysis (inverse-variance weighted: odds ratio, 1.26).
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