Malaria: New WHO consolidated guideline

 

The WHO recommendations for malaria, established by the WHO Global Malaria Initiative, are provided here as a comprehensive guide for malaria case management. The Global Technical Strategy for Malaria (GTS) establishes an integrated structure for malaria prevention and elimination activities from 2016 to 2030.

Both recommendations for managing uncomplicated and serious malaria in all age ranges and conditions, including in small children and pregnant mothers, are included in the integrated WHO guidelines for malaria.

Diagnosing malaria 

A parasitological examination (microscopy or RDT) should be performed on all probable cases of malaria to validate the diagnosis. A quality improvement method can be used to support both microscopy and RDTs.

 

Treating uncomplicated malaria

Artemisinin-based combination therapy for treating uncomplicated P. falciparum malaria

Using one of the following ACTs to treat adults and children with uncomplicated P. falciparum malaria (except pregnant mothers in their first trimester):

• Artemether + lumefantrine
• Artesunate + amodiaquine
• Artesunate + mefloquine
• Dihydroartemisinin + piperaquine
• Artesunate + sulfadoxine-pyrimethamine (SP)

 

Duration of treatment

Treating uncomplicated P. falciparum malaria and the duration of ACT treatment

Three days of therapy with an artemisinin analogue should be used in ACT regimens. Dosing of ACTs treating uncomplicated P. falciparum malaria in young children, the dosage guideline for dihydroartemisinin + piperaquine has been revised:

Dihydroartemisinin + piperaquine can be given to children weighing less than 25 kg for 3 days at a dose of 2.5 mg/kg bw dihydroartemisinin and 20 mg/kg bw piperaquine.

 

Treating special risk groups

1. Pregnant and lactating women in the first trimester of pregnancy- Treat pregnant women with uncomplicated P. falciparum malaria with quinine + clindamycin 7 days in the first trimester.
2. Infants and young children (infants weighing less than 5 kgs)- Treat children weighing less than 5 kg with ACT at the same mg/kg bw targeted dose as children weighing 5 kg if they have uncomplicated P. falciparum malaria.
3. Patients co-infected with HIV- Patients with HIV/AIDS and uncomplicated P. falciparum malaria should prevent artesunate + SP if they are taking co-trimoxazole, and artesunate + amodiaquine if they are taking efavirenz or zidovudine.
4. Treating uncomplicated malaria caused by P. vivax, P. ovale, P. malariae or P. knowlesi blood-stage infection- If malaria species are not recognised with certainty, treat as for uncomplicated.
5. Blood stage infection- Adults and children with uncomplicated P. vivax, P. ovale, P. malariae, or P. knowlesi malaria should be treated with either ACT (except pregnant women in their first trimester) or chloroquine in places where chloroquine-susceptible infections exist.
6. Adults and children with uncomplicated P.vivax, P. ovale, P. malariae, or P. knowlesi malaria (except pregnant women in their first trimester) should be treated with ACT in places where chloroquine-resistant infections exist.
7. Blood stage infection- Quinine should be given to pregnant women who have chloroquine-resistant P. vivax malaria in the first trimester.
8. Preventing relapse in P. vivax or P. ovale malaria- The G6PD status of patients can be used to direct primaquine administration for relapse prevention.
9. Preventing relapse in P. vivax or P. ovale malaria- To avoid recurrence treat P.vivax or P. ovale malaria in children and adults (with the exception of pregnant mothers, babies <6 months of age, breast-feeding infants <6 months of age, breast-feeding older infants unless considered to be G6PD deficient) with 14-day primaquine in all transmission environments.
10. Preventing relapse in P. vivax or P. ovale malaria- Consider providing primaquine base at 0.75 mg/kg bw once a week for 8 weeks to people with G6PD deficiency to avoid relapse, with appropriate medical monitoring for possible primaquine-induced haemolysis.
11. Preventing relapse in P. vivax or P. ovale malaria- Where G6PD status is uncertain and G6PD monitoring is not available, prescribing primaquine must be based on a risk-benefit analysis.

 

Treating severe malaria

Artesunate treating severe malaria:

1. Adults and children with significant malaria infection (including children, pregnant women in all trimesters, and lactating women) can receive artesunate intravenously or intramuscularly for at least 24 hours and before they can accept oral medicine.
2. Total medication with 3 days of ACT after a patient has had at least 24 hours of parenteral therapy and can tolerate oral therapy.
3. In small children, the dosage guideline for parenteral artesunate has been revised. To ensure adequate exposure to the medication, children weighing less than 20 kg should receive a higher dosage of artesunate (3 mg/kg bw per dose) than bigger children and adults (2.4 mg/kg bw per dose).
4. If artesunate is unavailable, treat children and adults with severe malaria with artemether rather than quinine.