Yazdy MM et al. – The data do not support an overall association between tea consumption and spina bifida, but there is a suggestion of a possible interaction between higher levels of folic acid intake and tea consumption.
Methods
- Using data collected in the Slone Epidemiology Center Birth Defects Study, they examined whether tea consumption during early pregnancy was associated with an increased risk of spina bifida.
- Mothers of 518 spina bifida cases and 6424 controls were interviewed within 6 months after delivery about pregnancy events and exposures.
- Data on tea intake were collected during three periods (1976–1988, 1998–2005 and 2009–2010).
- Logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs), adjusted for study center. Intake of both periconceptional food folate and diet and supplemental folic acid were examined as a potential effect modifier.
- For 1976 to 1988, ORs were not elevated for daily tea intake.
- For 1998 and onward, ORs were also close to 1.0, but there was a modest increase for those who drank more than 3 cups/day (OR, 1.92; 95% CI, 0.84–4.38).
- Among women with total folic acid intake greater than 400 μg, consumption of 3 cups or more of tea per day was associated with an increased risk of spina bifida in 1976 to 1988 (OR, 2.04; 95% CI, 0.69–7.66) and in the later periods (OR, 3.13; 95% CI, 0.87–11.33).
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