Officials from the Centers for Disease Control and Prevention (CDC) have
declared that Zika virus is a teratogen that causes microcephaly and
other serious brain anomalies. That conclusion was announced in a
special report in The New England Journal of Medicine which outlined the investigator’s systematic analysis of epidemiologic evidence on the virus to date.
The goal of the effort by CDC researchers was to determine whether
cause and effect could be established between prenatal Zika virus and
subsequent birth defects. The data on Zika virus were evaluated against
the criteria proposed by Shepard in 1994 as a “yardstick” for
establishing human teratogenicity.
The 4 key criteria of Shepard’s that the Zika virus has met, said the
CDC authors, and which justify the new classification, are as follows:
· Exposure to Zika virus occurs at a critical time in prenatal
development, as documented in a report of laboratory-confirmed
transmission in specific areas of Brazil and an increase in the number
of cases of microcephaly identified in the first trimester;
· Clinical cases with the teratogenic effect have been clearly
delineated, as seen in what the authors described as descriptions of the
typical pattern of findings in Zika-exposed fetuses and infants, such
as severe microcephaly, intracranial calcifications, and other brain
abnormalities; and
· Verification that the association involves a rare exposure and a
rare defect, as supported by evidence indicating that microcephaly is
rare in the United States, with an incidence of 6 per 10,000 live
births, and that adverse birth outcomes have been seen in offspring of
women who spent only a limited period of time in an area where Zika
virus was endemic.
With Zika virus confirmed as teratogenic, the CDC authors said, the
focus of research can now shift to “understanding the full spectrum of
defects caused by congenital Zika virus infection; if Zika virus is
similar to other teratogens…, quantifying the relative and absolute
risks among infants who are born to women who were infected at different
times during pregnancy…and identifying factors that modify the risk of
an adverse pregnancy or birth outcome.”
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