
Vaginal Discharge
Vaginal discharge is one of the commonest reasons women attend a clinic; most is normal or caused by bacterial vaginosis, candidiasis, or trichomoniasis, but cervicitis, pelvic inflammatory disease, and cancer can present the same way
Normal discharge is clear to white, odourless, non-itchy, and varies with the cycle; the vaginal pH is 3.8–4.5
Diagnose with a speculum examination, vaginal pH, the whiff test, and a wet mount rather than guessing from the smell or colour
Treat the cause: metronidazole for bacterial vaginosis and trichomoniasis, an azole for candidiasis, and treat the partner for trichomoniasis and gonorrhoea or chlamydia
Where tests are not available, use syndromic management as in the national programme, and always screen for HIV and syphilis
| Topic | Details |
|---|---|
| Normal discharge | Clear to white and thin, no smell, no itch; more mucus at mid-cycle (egg-white), in pregnancy, with arousal, and with hormonal contraception |
| Normal pH | 3.8–4.5, kept acidic by lactobacilli making lactic acid |
| What upsets it | Douching, scented products, antibiotics, diabetes, new partners, sex without condoms, pregnancy, and smoking |
| When it is abnormal | Change in colour, smell, or amount; itch, soreness, pain on passing urine or on intercourse; bleeding |
| Cause | Typical features |
|---|---|
| Bacterial vaginosis | Thin grey-white discharge with a fishy smell (worse after sex or periods), little itch; not sexually transmitted in the strict sense but linked to new partners |
| Vulvovaginal candidiasis | White curdy (cottage-cheese) discharge with itch, soreness, redness, and pain on passing urine; more common in pregnancy, diabetes, and after antibiotics |
| Trichomoniasis | Frothy yellow-green discharge, itch, smell, and a 'strawberry' cervix; sexually transmitted |
| Cervicitis (chlamydia, gonorrhoea) | Mucopurulent discharge, bleeding after sex or between periods, pain on passing urine; often no symptoms |
| Step | Details |
|---|---|
| History | Onset and duration, colour, smell, itch, pain, bleeding, last period, pregnancy, contraception, partners, condom use, previous infections, diabetes, drugs (antibiotics, steroids), and douching |
| Examine the abdomen | Lower abdominal tenderness and masses |
| Inspect the vulva | Redness, fissures, ulcers, warts, and the discharge at the introitus |
| Speculum examination | Colour and amount of discharge, the cervix (mucopus, friability, 'strawberry' spots), and any foreign body, growth, or fistula |
| Bimanual examination | If there is pain or fever: cervical motion tenderness, uterine or adnexal tenderness suggests pelvic inflammatory disease |
| Always consider | A pregnancy test and, in the right setting, cervical screening |
| Test | What it shows |
|---|---|
| Vaginal pH (swab on pH paper) | Above 4.5 in bacterial vaginosis and trichomoniasis; 4.5 or below in candidiasis and normal |
| Whiff test (10% potassium hydroxide on the discharge) | A fishy smell suggests bacterial vaginosis (or trichomoniasis) |
| Wet mount (saline) microscopy | Clue cells (bacterial vaginosis), motile trichomonads, and many white cells (cervicitis, trichomoniasis) |
| Potassium hydroxide wet mount | Yeast buds and hyphae in candidiasis |
| Amsel criteria for bacterial vaginosis | Three of four: thin homogeneous discharge, pH above 4.5, positive whiff test, clue cells (20% or more of epithelial cells) |
| Nucleic acid amplification tests | For chlamydia, gonorrhoea, and trichomonas (vaginal swab or first-void urine); culture or microscopy if not available |
| Other tests | Pregnancy test, blood glucose if recurrent candidiasis, and HIV, syphilis, and hepatitis B serology |
| Condition | First-line treatment (varies by guideline) |
|---|---|
| Bacterial vaginosis | Metronidazole 400 mg or 500 mg twice daily for 7 days, or metronidazole 0.75% gel or clindamycin 2% cream vaginally at night for 5–7 nights; partner treatment is not routinely needed |
| Vulvovaginal candidiasis | Clotrimazole 500 mg vaginal pessary as a single dose (or 200 mg for 3 nights), or fluconazole 150 mg by mouth as a single dose; treat only if symptomatic |
| Recurrent candidiasis (4 or more a year) | Confirm with culture, check for diabetes, induction with fluconazole then weekly fluconazole for 6 months (specialist advice) |
| Trichomoniasis | Metronidazole 500 mg twice daily for 7 days (or 2 g as a single dose in some programmes); treat the partner at the same time; avoid sex until both finish |
| Cervicitis (chlamydia, gonorrhoea) | Doxycycline 100 mg twice daily for 7 days plus ceftriaxone 500 mg intramuscularly once (or the national programme combination of azithromycin and cefixime); treat the partner and retest |
| Pelvic inflammatory disease | Ceftriaxone 500 mg intramuscularly once, doxycycline 100 mg twice daily, and metronidazole 400–500 mg twice daily, for 14 days; admit if unwell, pregnant, or no improvement |
| Atrophic vaginitis (after menopause) | Vaginal moisturiser or low-dose vaginal oestrogen; exclude other causes of bleeding |
| Group | Points |
|---|---|
| Pregnancy | Bacterial vaginosis and trichomoniasis are linked to preterm birth: test and treat with oral metronidazole (safe in all trimesters); candidiasis: use vaginal azoles for 7 days, not oral fluconazole; chlamydia: azithromycin 1 g, not doxycycline |
| Postmenopausal women | Atrophic vaginitis is common, but any blood-stained or persistent discharge needs examination, ultrasound, and biopsy if needed |
| Girls before puberty | Poor hygiene, worms, foreign body, and infection are common; blood-stained discharge or repeated infection needs a paediatric or gynaecology review; think of sexual abuse and involve a senior and child protection services |
| Women with an intrauterine device | Check for infection and the position of the device; do not remove it automatically unless severe infection |
| Women with HIV or diabetes | More frequent and persistent candidiasis and cervical disease; control glucose and screen the cervix |
| After delivery or abortion | Foul discharge with fever suggests retained products or endometritis; admit |
| Topic | Advice |
|---|---|
| Hygiene | Wash the vulva with water only; no douching, scented soaps, wipes, or sprays; cotton underwear; wipe front to back; change out of wet clothes |
| Safer sex | Condoms with new or multiple partners; partner treatment and no sex until both are treated |
| Test and screen | Offer HIV, syphilis, and hepatitis B tests; cervical screening at the right age and human papillomavirus vaccine for girls |
| Take the medicine fully | Finish the course; avoid alcohol while on metronidazole and for 24 hours after it |
| Follow up | Review if symptoms persist after treatment or return within 3 months; retest for chlamydia, gonorrhoea, and trichomonas after about 3 months |
| Do not | Treat every itch with an antifungal-steroid cream; use leftover antibiotics |
Treating by colour or smell alone without a speculum examination or pH test
Treating every discharge as candidiasis, especially with steroid combination creams
Forgetting to treat the partner in trichomoniasis, gonorrhoea, and chlamydia
Missing pelvic inflammatory disease because the pain is mild
Missing cancer in blood-stained or persistent discharge, or in postmenopausal women
Not testing for pregnancy, HIV, and syphilis
Using doxycycline or fluconazole in pregnancy

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