
Burning Micturition — Find the Cause, Test & Treat
Burning micturition (dysuria) means pain or burning on passing urine; the commonest cause is acute cystitis
E. coli causes about 86% of uncomplicated cystitis; others are Staph. saprophyticus, Klebsiella and Proteus
The history matters most: one classic symptom raises the chance of UTI from about 5% to about 50%
New dysuria and frequency with no vaginal discharge or irritation has about 90% positive predictive value for UTI
Vaginal discharge or irritation points to vaginitis or cervicitis rather than UTI
A midstream dipstick for nitrite and leucocyte esterase is enough for a typical case
Nitrofurantoin for 5 days is first-line in most guidelines; avoid fluoroquinolones as first choice
| Cause | Clues | Test |
|---|---|---|
| Acute cystitis | Dysuria, frequency of small volumes, urgency; sometimes haematuria; no discharge | Dipstick: nitrite, leucocyte esterase |
| Pyelonephritis | Fever, loin pain or tenderness, tachycardia, ill | Culture; consider ultrasound or CT if no response |
| Vaginitis: candida, bacterial vaginosis, trichomonas | Discharge, itch, irritation; burning when urine touches the skin | Speculum, vaginal pH, microscopy or swab |
| Urethritis, cervicitis (chlamydia, gonorrhoea) | New partner or partner with symptoms; discharge; lower abdominal pain (from memory) | NAAT or swabs from the endocervix |
| Genital herpes | Painful vulval ulcers or blisters; severe burning (from memory) | Swab for PCR (from memory) |
| Atrophic vaginitis | After the menopause; dryness, discomfort (from memory) | Examination |
| Stone, bladder pain syndrome, irritants, tuberculosis | Colic or haematuria; pain with a clean culture; soaps, spermicide or scented products; sterile pyuria (from memory) | Culture, imaging, further tests as clinically indicated |
Ask about onset, frequency, urgency, haematuria, fever, loin pain, discharge, itch, a new partner, spermicide or diaphragm use, diabetes, pregnancy, and recent antibiotics
Examine the temperature, suprapubic and loin tenderness, and look at the vulva; do a speculum if there is discharge
Collect a midstream clean-catch specimen; cleansing first makes no significant difference
Use a dipstick for nitrite and leucocyte esterase; both are the most accurate
Send a culture for suspected pyelonephritis, symptoms that persist or recur within 2 to 4 weeks, atypical symptoms, pregnancy, complicated cystitis, or relapse
A count of 10³ CFU/mL or more is diagnostic; over 10² CFU/mL with typical symptoms is positive
Do not send routine tests after treatment when she is well
| Tier | Drug | Notes |
|---|---|---|
| First line | Nitrofurantoin 100 mg twice daily for 5 days | Avoid if early pyelonephritis is suspected; take with food |
| First line | Fosfomycin 3 g single dose | May be less effective; availability varies |
| If local resistance is 20% or less | Trimethoprim-sulfamethoxazole 160/800 mg twice daily for 3 days | Avoid if used in the last 3 months |
| Alternative | Cephalexin 250 mg four times daily for 5 days | Beta-lactams are generally less effective than first-line drugs |
| Second tier | Ciprofloxacin 250 mg twice daily for 3 days | Reserve for allergy or serious infection; avoid fluoroquinolones first-line because of resistance |
| Complicated cystitis | Culture first; ciprofloxacin 500 mg twice daily or cefpodoxime 200 mg twice daily for 10 to 14 days | Choose by the culture; resistance to both drugs is common in India (from memory) |
| Pregnancy | Culture; treat according to the obstetric protocol | Asymptomatic bacteriuria in pregnancy: treat if more than 100,000 CFU/mL |
| Cannot take tablets, or pyelonephritis | Admit; IV ceftriaxone 1 g daily is one option | Adjust to the culture and local guidance |
| Cause | Treatment |
|---|---|
| Candidal vaginitis | Antifungal, vaginal or oral, as in your local protocol (from memory) |
| Bacterial vaginosis, trichomonas | Metronidazole; treat the partner for trichomonas (from memory) |
| Chlamydia, gonorrhoea | Treat per the current STI protocol, test and treat the partner, advise no sex until treated, offer HIV and syphilis testing (from memory) |
| Herpes | Antiviral and pain relief (from memory) |
| Atrophic vaginitis | Vaginal oestrogen (from memory) |
Finish the antibiotic even when she feels better, and come back if there is no improvement in 2 to 3 days
Drink enough water; pass urine after sex; wipe from front to back; avoid scented soaps and washes, and spermicide or a diaphragm if she gets repeated UTIs (from memory)
Return at once for fever, loin pain, vomiting or blood in the urine
If she has repeated UTIs: send a culture each time, consider low-dose prophylaxis or post-coital treatment, and in post-menopausal women vaginal oestrogen (from memory)
Treat her partner when a sexually transmitted infection is found
Treating every burning as a UTI without asking about discharge
Using a fluoroquinolone first, or repeating the drug she had in the last 3 months
No culture in pregnancy, relapse or suspected pyelonephritis
Giving nitrofurantoin when pyelonephritis is likely
Routine culture after treatment in a well woman
Treating asymptomatic bacteriuria in a non-pregnant woman (from memory)
Missing a sexually transmitted infection, herpes or genitourinary tuberculosis (from memory)
Forgetting diabetes (from memory)

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