A new vaccine candidate shows promise for preventing active pulmonary tuberculosis (TB) in adults infected with Mycobacterium tuberculosis. The vaccine, M72/AS01E, provided 54% protection against active pulmonary TB.
In a randomized, double-blind, placebo-controlled study, HIV-negative adults ages 18 to 50 with latent M tuberculosis were randomly assigned to receive 2 doses of the M72/AS01E vaccine or placebo a month apart. Researchers evaluated the safety and efficacy of the vaccine against progression to bacteriologically confirmed active pulmonary TB.
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